SYT1 Recombinant Alpaca VHH (SdAb2501.SYT1) – MiniMab™

Recombinant Alpaca VHH targeting the Synaptotagmin 1 (SYT1), part of Biotium’s MiniMab™ SdAb series that have been engineered for optimal conjugate performance.

Name SKU Size Availability Vendor Price Order

CF®488A

 N002-488A-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®498

 N002-498-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®568

 N002-568-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®583R

 N002-583R-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®647

 N002-647-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®660C

 N002-660C-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®680

 N002-680-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

CF®740

 N002-740-200UL 200uL Generally 1-2 weeks from receipt of order Biotium Log in for pricing

Features

SYT1 Recombinant Alpaca VHH (SdAb2501.SYT1) recognizes the Synaptotagmin 1 (SYT1) expressed in synaptic vesicles. This high-affinity single-domain antibody (SdAb), also known as camelid VHH or Nanobody®, is part of our MiniMab™ series of highly optimized conjugated probes. The SdAb has been validated for immunofluorescence microscopy and is available conjugated to CF® Dyes.

Features of MiniMab™ single-domain antibodies

  • Superior to conventional antibodies: deeper tissue penetration, higher solubility and stability, and faster staining
  • Minimal epitope-dye displacement—perfect for super-resolution imaging
  • Specifically developed and optimized for immunofluorescence
  • Labelled with bright, photostable CF® Dyes, including near-infrared CF®740 option
  • Available as conjugates with Biotium’s best-in-class dyes for STORM

Synaptotagmin 1 (SYT1) belongs to the synaptotagmin membrane-trafficking protein family comprising 17 members. These proteins are single-pass transmembrane proteins characterized by two calcium-binding domains within their intracellular segment. SYT1 is predominantly found in presynaptic boutons of axon terminals, where it associates with synaptic vesicles. It is critical in initiating vesicle fusion and facilitating neurotransmitter release in response to elevated calcium levels in the local environment.

This recombinant alpaca VHH binds specifically and strongly to the cytoplasmic region of rat and mouse SYT1 and is expected to also recognize human SYT1 due to high sequence similarity.

Learn more about CF® Dyes for super-resolution as well as Biotium’s innovative reagents for immunofluorescence microscopy; this includes our NucSpot® Nuclear Stains for bright and nuclear-specific staining in a wide colour selection, and CytoLiner™ Fixed Cell Membrane Stains for robust membrane staining in formaldehyde-fixed cells.

View Biotium’s full selection of primary and secondary antibodies available with bright CF® Dyes and other labels.

Resources

Protocols for Antibody Based Detection:

SDS:

Datasheet:

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