Check out the latest news from Biotium USA, a leading provider of innovative fluorescent solutions for scientists.
Biotium is devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery.
Since its founding in 2001, Biotium has developed over 30 patented technologies including GelRed® dyes, CF® Dyes, NucView® Caspase-3 Substrates, EvaGreen® Dyes, and TrueBlack® Background Reducers.
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Biotium | DNase pre-treatment of the EV exterior improves EV RNA yield
Extracellular vesicles (EVs) are known to contain RNA, including microRNA (miRNA) and mRNA, derived from the cell of origin. Studying EV RNA can be useful for many purposes: determining the cellular source of the EVs, for disease diagnostics (Ref. 1), and for identifying oncogenic RNAs (Ref. 2). Since EVs are very small (~30-200 nm in […]
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Biotium | ExoBrite™ CTB EV Stain assists in evaluating engineered EVs for targeted drug delivery against triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive cancer type with no specific therapeutic targets, leaving chemotherapy as the primary treatment option. However, chemotherapy is often highly toxic for patients with limited effectiveness, underscoring the need for new therapeutic strategies. Researchers are examining the potential of extracellular vesicles (EVs)- small, cell-derived particles that are naturally highly […]
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Biotium | MitoView™ 633 offers advantages over TMRM as a probe for mitochondrial membrane potential
Mitochondria are essential for maintaining cellular health, with a key aspect of mitochondrial function being the mitochondrial membrane potential (mitochondrial potential). Mitochondrial potential is a valuable biomarker for detecting any disruptions linked to mitochondrial dysfunction. This is because it reflects the electrical gradient central to processes like ATP synthesis and calcium homeostasis across the inner […]
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Biotium | Bright and photostable CF® Dyes help validate fluorescence lifetime separation in multi-colour imaging
Fluorescence lifetime imaging microscopy (FLIM) has emerged as a powerful technique for multi-colour imaging, allowing researchers to distinguish fluorochromes beyond traditional spectral separation methods. By leveraging fluorescence lifetime differences, FLIM provides additional fluorochrome discrimination, enabling more complex imaging experiments with fewer spectral constraints. This approach is particularly valuable in confocal and Stimulated Emission Depletion (STED) […]
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Biotium | New MiniMab™ Single-Domain Antibody Series Provides Super-Resolution Imaging Options for Neuroscience Research
Biotium’s New SYT1, VGLUT1, and GFAP Recombinant Alpaca SdAb conjugates offer exceptional performance for STORM imaging with CF® Dyes Fremont, CA — July 7, 2025 — Biotium, a leading innovator in life science reagents, is proud to support the advancement of super-resolution imaging with the release of their MiniMab™ single-domain antibody (SdAb) series. The MiniMab™ […]
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Biotium | Tech Tip:Using ViaFluor® SE Stains for Cell Tracing and Co-Culture
ViaFluor® SE Cell Proliferation Kits ORDER HERE CellBrite® Cytoplasmic Membrane Dyes ORDER HERE ViaFluor® SE Cell Proliferation Kits use amine-reactive dyes to covalently label cells throughout the cytoplasm and intracellular compartments. ViaFluor® SE dyes are initially membrane-permeable and non-fluorescent. After the compound enters viable cells, it is hydrolyzed by cytoplasmic esterases to releases the […]
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Biotium | Cellular Stains Selection Guides
Compare applications, fixability, cellular targets, and staining in different organisms at a glance. For more detailed information, see our Cellular Stains Technology Page and Membrane & Cell Surface Stains Comparison. Download our Cellular Stains Brochure or visit our Brochure Library to browse our product flyers. Cellular Stains Selection Guide (NEWLY UPDATED!) DOWNLOAD HERE […]
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Biotium | Literature Digest Viral Integrity with PMA & PMAxx™
Literature Digest Viral Integrity with PMA & PMAxx™ PMA (Propidium Monoazide) ORDER HERE PMAxx™ Dye, 20 mM in H2O ORDER HERE PMA & PMAxx™ combined with qPCR is a well-published method for sensitive, accurate, and rapid detection of intact viral capsids. In this digest, we have selected three publications with summaries and takeaways on […]
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Biotium | PMAxx™ q-PCR: an effective tool for detection of seed-borne pathogens
PMAxx™ Dye, 20 mM in H2O ORDER HERE Seed health is important for good yields and maintaining desired plant traits, as well as for minimizing the spread and dispersal of plant pathogens. The certification of pathogen-free seeds is an effective strategy to prevent and manage disease. This approach, however, is highly dependent on a reliable […]
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Biotium | Monitoring Viable Bacteria in the Environment
Monitoring Viable Bacteria in the Environment with PMA and PMAxx™ PMA (Propidium Monoazide) ORDER HERE PMA-Lite™ 2.0 LED Photolysis Device ORDER HERE Viability PCR (v-PCR) with PMA and PMAxx™ has been validated in hundreds of peer-reviewed publications and numerous microbial strains for sensitive, accurate, and rapid detection of viable microbes. In this digest we […]
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